Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furocho,Chikusa-ku, Nagoya 464-8601, Japan.
The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added to the drinking water (300 mg/kg/day). In vivo glucose utilization was measured by the euglycemic clamp technique. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle were performed afterwards by Western blotting. At 3 mU/kg/min insulin infusions, the decreased glucose infusion rate (GIR) in HFD-fed rats (60 % of controls, p < 0.01) was improved by CE administration to the same level of controls (normal chow diet) and the improving effect of CE on the GIR of HFD-fed rats was blocked by approximately 50 % by Nmonometyl- L-arginine. The same tendency was found during the 30 mU/kg/min insulin infusions. There were no differences in skeletal muscle insulin receptor (IR)-beta, IR substrate (IRS)-1, or phosphatidylinositol (PI) 3-kinase protein content in any groups. However, the muscular insulinstimulated IR-beta and IRS-1 tyrosine phosphorylation levels and IRS-1 associated with PI 3-kinase in HFD-fed rats were only 70 +/- 9 %, 76 +/- 5 %, and 72 +/- 6 % of controls (p < 0.05), respectively, and these decreases were significantly improved by CE treatment. These results suggest that early CE administration to HFD-fed rats would prevent the development of insulin resistance at least in part by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle.
Source: PMID: 15002064 [PubMed - indexed for MEDLINE]
A study was conducted by the University of Peshawar, Pakistan on 60 individuals (30 men and 30 women) with Type 2 Diabetes. All patients were over 40 years of age. They were all on anti-diabetic medication, not on insulin and consumed their normal diets throughout the study. The addition of 1,3 or 6 grams of cinnamon to the diet for 40 days caused blood sugar levels to decrease by 18 to 29%, triglycerides by 23-30% LDL cholesterol by 7-27% and total cholesterol by 12-26%. There were no problems with taking the cinnamon supplement.
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